Finally, the next generation of chemical reacting technology:

At a Glance

Millions Invested 22
People Years Invested 40
Average Independent Claims 3
Average Dependent Claims 15
Nominal Expiration Range 8/15/2028 - 5/16/2031

Built on deep knowledge of turbulent and laminar flow mixing, the Holl-Reactor™ was designed to mix more quickly and uniformly than anything designed before it. Scaling up of processes from lab-scale to pilot-scale to commercial-scale manufacturing are simplified by the reactor’s unique design, decreasing risk during the fundamental step in the realization and optimization of industrial plants.

Suitable for bench-scale, pilot-scale, and large-scale manufacturing, the unique Holl-Reactor™ has the ability to create perfectly uniform reagents for small and large scale operations. Instantaneous throughput allows for immediate results when you need it, at the uniformity required! Not just theory, Holl-Reactors™ have been built and deployed in numerous real world applications as diverse as petrochemical manufacturing and liquid crystal display chemical production.

Top View

Depending on the chemical reaction involved and annular gap chosen, the reactor can be scaled to meet a full range of pilot and commercial-scale applications. Additionally, the Holl-Reactors™ self-cleaning capabilities are second to none, dramatically reducing manufacturing set-up and switch over costs (<2 seconds and 0 ppm contaminants left, when mixing milk and molasses, for demonstration).

The reactor demonstrates excellent selectivities and yields, which are achieved in seconds by first converting both reagent “volume” flows, as they enter the reactor chamber, into forward flowing “film” flows. These flows are then made to converge “edge on” along a singular and precisely defined contacting line, enabling the reaction to begin nearly instantaneously under micro-mixed conditions. For higher yields, the reactor can be scaled vertically and/or multiple units installed.

Until recently, in modern chemical reactor design, baffle assisted, propeller stirred tanks, static mixers, spinning disc and oscillatory flow reactors have become the state of the art for achieving improved chemical product yield, selectivity and uniformity of production. In a world of only incremental improvements in reactor design, the Holl-Reactor™ stands apart for its radical, trailblazing, truly cutting edge innovation, representing a veritable turning point in chemical reactor technology.

Interior Reaction View

Given the reactors “instantstart” micro and macro mixing, small footprint, and surprisingly low power consumption, the Holl-Reactor™ should be considered a primary candidate for all industrial mixing and reacting applications. The reactor can be manufactured with a wide range of materials. For example, using a chemically inert boron silicate for the rotor combined with Hastelloy C-22 for the stator, provides a configuration ideal for highly corrosive mixing applications. No matter the customer material specifications, the reactor capitalizes on an absence of seals, shafts and bearings for breathtaking operational simplicity. The hermetically enclosed and inert construction2 is magnetically driven on a freely floating rotor, preventing fouling or scaling. This drives down-time for preventative and unexpected maintenance to nearly zero, providing significant economic benefit. The Holl-Reactor’s™ ability to easily accommodate water jackets (hot or cold) and other thermal control mechanisms makes it the ideal candidate for reactions requiring tight temperature control.


  • Chemical Synthesis
  • Non-Lysing Bioreacting
  • Oxidative Petroleum Desulfurization
  • Reverberatory Ultrasonic Micro-Mixing
  • Emulsifications
  • Ultra-enhanced process heat transfer
  • Planetary Paste-mixing
  • Cosmetic Products
  • High-tech Ceramics
  • Perfect-ratio-mixing
  • Flat Panel Display Chemicals
  • Fine/Specialty Chemicals
  • Highly Exothermic Compounds
  • RDX and other Explosives
  • Active Pharmaceutical Ingredients (APIs)

This IP Value is comprised of 2 U.S. patents, and associated trade secrets. Patent 7,780,927 covers the Spinning tube in tube reactor and its method of operation. This patent came into effect in 2008, and is valid until 2028. Patent 8,298,493 covers the heat exchange apparatus for a thermally controlled reactor, which came into effect in 2010, and is valid until 2030. Both have had an IP valuation firm engaged to provide Patent-level assessment, ranking Patent 7,780,927 and 8,298,493 an A in untapped innovation.

Considerable research has been conducted in the domain of forced reactors since the 1990s. In the last 20 years, more than 1,900 patents have been filed across countries. However, none of which have the capabilities of Holl-Reactor. This is the future of synthesis, available today!

  • Significantly reduce cost and number of steps of syntheses
  • Increase speed of production by orders of magnitude
  • Increase purity and quality of products
  • Drastically reduce energy consumption
  • Drastically reduce organic solvent use
  • Totally remove manufacturing hazards of exothermic reactions
  • Speed up development of active pharmaceutical ingredients (APIs)
  • Render the fashionable micro-reactor technology obsolete
  • Allow lowering cost of continuously synthesizing bio-diesel

Crude Oil Neutralization: A Holl-Reactor™ made of a glass stator and a 10” diameter, 26” long steel rotor was used to continuously neutralize naphthenic acids with a slaked lime suspension. It neutralized 85% in a single pass through the reactor to yield calcium naphtenate. A cluster of ten 6 ft diameter Holl-Reactors™ can neutralize the naphthenic acids of California crude oil at a rate of 500 gal/min.

Desulfurization of Petroleum Fuel to < 4 ppm: The Holl-Reactor™ was tested in this case for a flow rate of 50 ml/min, at a reactor spin rate of 3,000 rpm under the supervision of the world renowned Dr. Octave Levenspiel. At throughput rates of 1,000 gal/min. can be achieved, using a cluster of fifteen 6 ft. diameter Holl-Reactors™ in parallel.

Sodium Salt of Phenoxy Acetic Acid, SPA: A Holl-Reactor ™ at a throughput of 0.5 L/min. For this highly corrosive application, the rotor was made of Macor® boron silicate and the rotor of Hastelloy C-22. 32 L/min in a single 4.0 ft diameter Holl-Reactor can be achieved, made of chemically inert materials.

Manufacturing of Liquid Crystal Display Chemicals: Using a 100 ml/min throughput Holl-Reactor™ made of customer specified rotor and stator materials. A single Holl-Reactor™ unit of 4.0 ft diameter has the potential to create at a rate of 6 L/min.

Comminution of RDX Rocket Propellant: In a corrosion resistant Holl-Reactor™, RDX crystals, suspended in a solvent were successfully comminuted ultrasonically from 70 microns to 5 microns in a continuous flow-through, ultrasonic Holl-Reactor™. Flow rates of 1 to 2 L/min can be achieved in a 4.0 ft diameter Holl-Reactor™.

Manufacturing Electronic Dielectric materials: A Holl-Reactor™ unit can produce 500 ccm of ceramic-polymer paste per min for the production of composite circuit boards and unidirectional GHz chip antennas. These mirror-pressed, ceramic-polymer composite substrates, not only substantially reduce cost, but also improve microwave hybrid circuit performance. A single Holl-reactor, followed by a substrate press can produce 400 mirror-finished substrates, measuring 5” x 5” x 30 mil. This can easily be scaled up to a mass production of 4,000 ceramic-polymer composite substrates per hour. Metallization of one or two sides of the substrates would occur at the same rate.

Time-to-value is of paramount importance for licensees, and Know-How—when available—enables quick utilization of new assets with reduced risk, greatly accelerating your time-to-value.

A meticulously cataloged set of know-how is available to assist licensees. Significant purchases include consulting by the key inventor of the technology, managed by agencyIP’s follow-up tracking system. Available know-how for the two patents associated with this value proposition includes:

  • R&D Documentation
  • Scalability & Process Analysis
  • Material Specifications
  • Consulting from Technology Inventors
  • Patent Numbers

    US: 7,780,927; 8,298,493

    Patent Type: Utility: Non-Provisional

  • Application Numbers


  • Owner
    Holl Partners, LLC
  • Approximate Patent Expiration
    2/20/2028; 12/17/2030
  • Current Customers/Licensees
    Fortune Companies & Research Facilities
  • Affiliated Institutions

Contact Us

3945 Freedom Circle, Suite 560
Santa Clara, CA 95054

Phone:  (877) 501-4794
Fax: (877) 501-4795


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